Umbilical Cord MSC and Autoimmune Diseases

Kamen et al. (2022) evaluated umbilical cord MSC use in patients with systemic lupus erythematosus (SLE) refractory to conventional treatments, observing immune response modulation and disease activity improvement in most patients.

How do they act?

MSCs and their exosomes can modulate the immune system through different mechanisms:

Regulate B cell and other immune cell activity.

Help reduce inflammatory processes.

Support a more tolerant, balanced environment.

Modulate communication between immune system cells.

Umbilical cord MSCs represent a promising approach in immune response modulation for autoimmune diseases.

Clinical study

Kamen et al. (2022)

Most patients showed improvement in SLE activity after treatment with UC-MSC.

Key findings

Changes in B cell populations.

Immune response modulation.

Improvement in disease activity.

New perspectives for a future with more possibilities

Scientific reference

Kamen DL. et al. (2022).

Safety, immunologic and clinical response in a phase I trial of umbilical cord mesenchymal stromal cells in patients with treatment refractory SLE.

Lupus Science & Medicine, 9(1), e000704.

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