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Scientific evidence

Umbilical cord MSC and exosomes

in sports injuries

Preclinical and clinical studies have shown that umbilical cord MSCs and their exosomes may support the repair of tendons, ligaments, muscle and cartilage, reducing inflammation and improving tissue quality.

Reduce inflammation
Stimulate collagen production
Support tissue regeneration
Promote angiogenesis
Speed up return to physical activity
Rodilla de deportista con MSC y exosomas

Umbilical cord MSC exosomes

Extracellular vesicles with bioactive molecules for tissue repair.

Tissue repair at the cellular level

Yao et al. (2021)

Preclinical study

Achilles tendon injury

Umbilical cord MSC exosomes improved tissue organization, increased collagen production and supported tendon repair in experimental models.

Yao et al. (2021) Before

Before

Yao et al. (2021) After

After

Achilles tendon ultrasound (better tissue organization)

Type I collagen expression

Control
+70%
UC-MSC exosomes

Lo et al. (2024)

Preclinical study

Anterior cruciate ligament injury

Umbilical cord MSC exosomes supported ligament cell proliferation and migration and stimulated collagen production in experimental models.

Lo et al. (2024) Before

Before

Lo et al. (2024) After

After

Knee MRI (improved ligament integrity)

Tissue repair markers

ControlUC-MSC exosomes
+65%
Collagen I
+80%
Cell proliferation

How is recovery assessed?

Ultrasound(soft tissues)
MRI(ligaments and cartilage)
X-ray(bone follow-up)
Functional tests(strength and mobility)

Results observed in studies

  • Better tissue quality on imaging (ultrasound and MRI).
  • Reduced pain and inflammation.
  • Greater recovery of joint function.
  • Faster return to sports activity.
Deportista corriendo

Recoveryour best version

Yao Z. et al. (2021).

MicroRNA-engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling.

Journal of Nanobiotechnology, 19, 169.

Lo HL. et al. (2024).

Effect of lyophilized exosomes derived from umbilical cord stem cells on chronic anterior cruciate ligament cell injury.

Journal of Orthopaedic Surgery and Research, 19, 554.

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